Rosuvastatin

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Q: Can someone who is taking Rosuvastatin for cholesterol let me know how they are doing!?
I have been asked to take this for high cholesterol. Would like some feedback from people who are already on this medication.

A: Rosuvastatin is used together with lifestyle changes (diet, weight-loss, exercise) to reduce the amount of cholesterol (a fat-like substance) and other fatty substances in your blood. Rosuvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body.
Buildup of cholesterol and other fats along the walls of the blood vessels (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to the heart, brain, and other parts of the body. Lowering blood levels of cholesterol and fats may help to decrease your chances of getting heart disease, angina (chest pain), strokes, and heart attacks. In addition to taking a cholesterol-lowering medication, making certain changes in your daily habits can also lower your cholesterol blood levels. You should eat a diet that is low in saturated fat and cholesterol, exercise 30 minutes on most, if not all, days and lose weight if you are overweight.

Q: Rosuvastatin & Birth control pills (Ortho Tri-Cyclen Lo)?
Will Ortho Tri-Cyclen Lo still be an effective form contraception if taken with 5mg of Rosuvastatin? Both will be taken daily.

Thanks.

A: Hello,
I just looked your medication up on the internet and it looks ok to use it with birth control and I saw nothing that said other wise. It said do not take with other diet maedications you can look it up punch in Rosuvastatin and it pops right up. Good Luck.

Q: Is there any side effects when taking Rosuvastatin with CoQ10?

A: COENZYME Q-10 may interact with ROSUVASTATIN

“Some of the prescription cholesterol-lowering drugs that belong to a drug class known as HMG Co-A reductase inhibitors (statins) are known to decrease the amount of coenzyme Q-10 in the body. A few individuals who take statins may develop cramps, pain and/or weakness in their muscles. Very rarely, a more severe condition known as rhabdomyolysis, which may include muscle deterioration and kidney damage, has been associated with taking statins. Individuals who take a statin and who develop unusual muscle pain or weakness should contact a doctor right away. Although possible results of coenzyme Q-10 deficiency have not been identified, some very early research seems to show that decreased levels of coenzyme Q-10 and other natural substances may contribute to statin-related muscle conditions. Whether taking coenzyme Q-10 while a statin is also taken will prevent or lessen possible statin side effects is not yet known, however. ” Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems

Q: Rosuvastatin – What’s the latest on this drug? Can it be prescribed in the UK?
I remember reading in 2006 sometime about the drug Rosuvastatin actually being able to reverse the furring of the blood vessels and reversing the problems people have with this condition (like high cholesterol).

Is this drug available on the NHS? Have their been further studies? Would a GP prescribe this, if the patient suggested it?

My dad has high cholesterol and has chest pains when he exerts himself too much. From what I’ve been told, he has high cholesterol and what he says as ‘furring of the blood vessels’.

I’m just trying to find out if this drug will help him. He’s currently on Atorvastatin.

A: Neither drug will help. Actually they damage the heart increasing the incidence of congestive heart failure. They cause permanent muscle damage through mitochondrial mutations. Is he over 50? They have never shown any beneficial effect for men over 50 or women of any age.
Pharmacist who’s life was almost ruined by Lipitor (atorvastatin)

Q: how much for rosuvastatin 10mg (Crestor)?
I was just put on this but haven’t been able to find a price for this prescription. I do know that it doesn’t fall under walmarts 4.00 plan, but can’t find a generic price.

A: You can make small payments at this website…so it says. Hope this helps you out a bit. Good Luck!

Q: benefit of rosuvastatin versus atorvastatin?

A: Crestor verses Lipitor. Crestor is more potent by quite a lot. 80mg of Lipitor = 10mg of Crestor in terms of cholesterol lower power. Sometimes people who at or near the dosing scale with Lipitor and are not achieving cholestrol goals, then Crestor can be used alternatively. Additionally as you near the maximum dosing for Lipitor people will have more adverse effects. Substituting Crestor at 2.5mg or 5mg sometimes gives equivlent potency and results, with no side effects. Usually its the muscle aches that bother people. Try this alternative and you can still use a statin and the patient will be free of side effects.

As you may have heard this week a study was released showing those on a maximum dose of Crestor, there was actual reversal of plaques in the coronary arteries. There was a similiar study done with Lipitor at maximum dose and it showed reversal of plaques in a few patients. I think the key to plaque reversal is to get the LDL down in 50 range. There has yet to be studies showing fewer end events with this therapy, but I am sure someone will be working on it. Stay tuned.

Q: could there be reason to believe an improvement in cholesterol readings have reduced atheroscolosis?
my father’s cholesterol levels have been gradually improving in the past 18 months since starting rosuvastatin (Crestor). Even though I do not have the exact readings with me currently. I am well aware that his LDL and triglycerides are significantly dropping and HDL levels have also increased although not dramatically.

What I would kindly like to know is does an improvement in cholesterol readings have reduced the amount of blockages in his arteries?

A: I have to disagree with the above poster. I don’t think clogged arteries ever start to open up. They might to a minimal degree…but once you have atherosclerosis, the goal is to prevent it from getting worse. I know of no treatment to date that will make them go away.
For instance, I have never heard of a 60 y.o. man with clean coronaries, after being on Crestor for 20 years and keeping his LDL really low. It just doesn’t happen.

Q: What are the interactions between these drugs?
Amlodipine
Bupropion
Desloratadine or Ebastine
Escitalopram
Levofloxacin Tablets
Lisinopril
Rosuvastatin
hydrochlorothiazide
caffeine
Alcohol (Maximum 2 drinks)
Food
Grapefruit juice may block the breakdown of amlodipine by the liver. If this happens, blood levels of amlodipine could be increased and that could increase the risk for side effects.
Levofloxacin Tablets decrease the Seizure threshold?

A: I would not expect Anyone here to answer such an complex question first of all.

Second..I would not trust this site for that kind of info.

Check with a pharmacist!

Q: help help help…biochemistry….what is Km value for an enzyme inhibitor?
that ..” the statin Rosuvastatin has a better affinity to a target enzyme as determined from apparent Km value”
In simple can you please explain to me what the “Km value” means?..
and y is rosuvastatin better than previously developed Lovastin(in terms of Km)?
and is the Rosuvastatin a competitive, non-competitive or an uncompetitive inhibitor?
I need the answer soon>
Thanks>

A: i believe km is the affinity of the enzyme to bind to its substrate.

http://en.wikipedia.org/wiki/Rosuvastatin

sorry i dont have any more information regard rosuvastatin and lovastin

Q: advice on toe cramps?
pls can anyone help me? i have been taking rosuvastatin to lower my cholesterol level, the trouble is in the evening i am waking up with awfull cramps in my toes, its a side afect of the meds, does anyone know how i can ease the pain and would cold be better than hot e.t.c thanks, and happy new year

A: I suffer from a similar problem, but in my legs. I have found that drinking a glass of tonic water every day helps. It is the quinine in the drink that does the trick, and is easier than taking quinine tablets. If you don’t like the taste of tonic water, add fruit juice (not gin!).

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